![]() ![]() Previous studies in Uganda have established an association between HIV infection and cancers with the prevalence ranging from 23 to 57%. ![]() The number of documented new cancer cases has increased over the past years in Uganda with approximately 4,000 cancer patients in registered in 2016 and 1,500 cancer-related deaths. Uganda had an estimated 1.4 million people living with HIV in 2019, and in the same year approximately 23,000 people died of AIDS-related illnesses. Some of the cancers that have been associated with HIV infection include Kaposi sarcoma, cervical cancer, lymphoma,anal cancer, lung cancer and hepatocellular carcinoma. ![]() People Living with HIV (PLWH) are at an elevated risk of developing cancer, and have a higher incidence of both AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) due to HIV-induced immunodeficiency compared with the general population. Recently, there has been a rise in cancer among the people living with HIV (PLWHIV) with nearly 25–35% of the global HIV-associated deaths occurring among cancer patients and Sub-Saharan Africa (SSA) bears the greatest burden. Globally, an estimated 37.7 million people were living with HIV in 2020, and about 680,000 died due to AIDS-related illnesses in the same year. Furthermore, Integration of HIV- cancer care will be necessary for efficient and effective care for the patients. There is a need to provide information on the stage of cancer and adherence counseling to patients. Factors significantly associated with adherence were: knowledge of the cancer stage by the patient, the type of cancer diagnosis, source of ART and affordability/ availability of medications. ConclusionĪdherence to both ART and cancer chemotherapy was low. ![]() Patients with good adherence to antiretroviral therapy and chemotherapy were 54%. The mean age of the respondents was 42 (SD ± 11years), and a majority, 61% were males.More than half, 56.5% were married and at least 45% had attained a primary level of education. Overall, 54% of the study participants adhered to both ART and chemotherapy, and 55% adhered to ART while 65% adhered to cancer chemotherapy. Modified Poisson regression with robust standard errors was used to estimate the prevalence ratios (PR) and its 95% confidence intervals (CI) for the factors associated with adherence to Antiretroviral Therapy (ART) and cancer chemotherapy. We collected the data using interviewer administered semi-structured questionnaires. Antiretroviral and anti-cancer chemotherapy adherence with associated factors were assessed quantitatively. We conducted a cross-sectional study among 200 randomly selected adult cancer patients infected with HIV and attending the Uganda cancer institute. We aimed to determine adherence to antiretroviral and cancer chemotherapy and the associated factors among patients with HIV-cancer co-morbidity at the Uganda Cancer Institute. There has been an increase in cancer among HIV patients which has resulted into use of co-medications that sometimes affect ART and cancer chemotherapy adherence. Human Immunodeficiency Virus is a major global public health issue affecting millions of people, and sub-Saharan Africa where Uganda lies is disproportionately affected. ![]()
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